Ultrasound-Assisted 3-component reaction in acetic acid alone: Catalyst/promoter/ligand free synthesis of bioactive pyrazolo [1, 5-a] pyrimidines

1 10 2017

Authors: Namburi Suresh, Bodapati Veera Durgarao, A Ratnakar, Sunder Kumar Kolli, Mohd Ashraf Ashfaq, Mandava V. Basaveswara Rao, Manojit Pal

Background Acetic acid alone when employed as a solvent under ultrasound irradiation has been found to be effective for the three-component reaction involving ethyl-5- amino-1H-pyrazole-4-carboxylate, aromatic aldehydes and terminal alkynes in the presence of aerial oxygen. Methods The catalyst / promoter / ligand free method afforded a range of pyrazolo[1,5-a] pyrimidines as potential and new cytotoxic agents. Results and Conclusion While some of these compounds showed cytotoxicities against two breast cancer cell lines one of them was found to be promising.